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Study: Cells that results in neuronal death


Nepalnews
2022 Jul 13, 18:26,
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According to a recent study, a type of central nervous system cell, Microglia is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease. This research was measured by using a mouse model of the disease.
The findings of the study were carried out by a group of researchers from Institut de Neurociencies of the Universitat Autonoma de Barcelon and were coordinated by investigator Juan Hidalgo from INc and the Department of Cell Biology, Physiology and Immunology of the UAB. The results were published in the journal GLIA.
Leigh Syndrome is the most common form of mitochondrial disease. The cause of this group of diseases is a malfunction of the mitochondria -- the organelles responsible for generating energy for the cell to function properly -- caused by mutations in mitochondrial RNA or cellular DNA. In Leigh Syndrome, organs and tissues that need more energy, such as muscles or the brain, cannot function normally, causing very serious motor and respiratory problems in people who suffer from it.
Previous studies had described high neuroinflammation in the brains of Leigh Syndrome mouse models, but its effect on the development of the disease was unknown: protective, harmless, or harmful. In the present study, researchers found that inflammation causes neuronal death and that the main element responsible for this process is microglia cells. These cells, which under normal conditions defend the nervous system from external or internal aggression, attack neurons with mitochondrial dysfunction, causing their death.
In the study, researchers analyzed the effect of suppressing microglial cells using a drug, Pexidartinib (PLX-3397). "With the removal of microglia, it took longer for motor problems to appear, and life expectancy was higher. In addition, when studying their brains, we found that there was much less neuronal loss," says Kevin Aguilar, first author of the article. "This drug, although it is not a good candidate for treating the disease, has been a key tool in identifying the effect of the neuroinflammation process and understanding how neuronal loss occurs," he adds.
The study also looked at the role of IL-6, a protein that modulates inflammatory activity and guides the activity of microglia. "We suspected that this protein would also play a key role in the symptoms of the syndrome. That's why we wanted to analyze what happened when there was a deficiency. However, contrary to what we expected, although respiratory problems were reduced, the effects were very moderate. This makes us think that there are other proteins involved," explains Aguilar. "Our next goal will be to describe the specific process by which microglia cells attack neurons and thus be able to develop more specific and selective treatments in the future," he concludes.

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Microglia neuronal death Leigh Syndrome symptoms mitochondrial disease Neurological study generating energy Organs tissues protein treatments
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